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Multiple Choice

Which exotoxins are produced by anthrax?

Anthrax produces two exotoxins that are delivered into cells as binary toxins. These are edema toxin and lethal toxin. Edema toxin consists of edema factor (an adenylate cyclase) paired with protective antigen, which raises intracellular cAMP and causes edema and immune dysfunction. Lethal toxin consists of lethal factor (a zinc-dependent metalloprotease) paired with protective antigen, which disrupts signaling and leads to cell death and shock. Protective antigen itself is not a toxin by itself; it serves to deliver EF and LF into cells. The capsule is not an exotoxin. So the two exotoxins produced are edema factor and lethal factor.

Anthrax produces two exotoxins that are delivered into cells as binary toxins. These are edema toxin and lethal toxin. Edema toxin consists of edema factor (an adenylate cyclase) paired with protective antigen, which raises intracellular cAMP and causes edema and immune dysfunction. Lethal toxin consists of lethal factor (a zinc-dependent metalloprotease) paired with protective antigen, which disrupts signaling and leads to cell death and shock. Protective antigen itself is not a toxin by itself; it serves to deliver EF and LF into cells. The capsule is not an exotoxin. So the two exotoxins produced are edema factor and lethal factor.